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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Curr Opin Chem Biol. 2009 Nov 10;14(1):37. doi: 10.1016/j.cbpa.2009.10.012

Figure 2. Compartmentation of signaling components confer specificity on various scales.

Figure 2

Left: Distinct localization of lipid second messengers (PI(3,4,5)P3) and active small GTPases Rac and RhoA plays important roles in establishing neutrophil polarity and promoting chemotaxis. Right: Specific localization of PKA and PDE isoforms confer specificity of signaling through various GPCRs by establishing cAMP signaling microdomains within cardiomyocytes.