Table 2.
Therapeutic outcomes of cyclophosphamide therapy for inflammatory eye disease
| Outcome | Uveitis | Scleritis | Mucous Membrane Pemphigoid | Other | Total |
|---|---|---|---|---|---|
| Used as only immunosuppressive drug therapy | 44 | 48 | 98 | 25 | 215 |
| Treatment Success At Or Before 6 months, % (95% Confidence Interval(CI)) | |||||
| Controlled Inflammation - No Activity at 6 months | 50.2 (33.8 - 69.2) | 53.3 (37.4 - 71.0) | 43.0 (33.0 - 54.5) | 72.0 (49.1 - 91.0) | 49.2 (41.7 - 57.2) |
| Controlled Inflammation - No Activity or Slightly Active at 6 months | 52.5 (34.4 - 73.1) | 61.5 (45.1 - 78.1) | 56.4 (45.4 - 68.0) | 78.0 (55.0 - 94.3) | 58.9 (51.0 - 67.0) |
| Corticosteroid Sparing -Controlled Inflammation and Prednisone ≤ 10 mg/day | 30.9 (18.3 - 49.1) | 30.2 (17.8 - 48.1) | 25.6 (17.6 - 36.3) | 50.2 (29.1 - 75.7) | 30.1 (23.8 - 37.6) |
| Corticosteroid Sparing -Controlled Inflammation and Prednisone ≤ 5 mg/day | 29.4 (17.0 - 48.0) | 17.9 (8.91 - 34.1) | 19.7 (12.7 - 29.8) | 33.6 (17.3 - 58.6) | 22.8 (17.3 - 29.7) |
| Corticosteroid Sparing -Controlled Inflammation and Prednisone = 0 mg/day | 5.71 (1.46 - 21.0) | 0.00 (0.00 - 0.00) | 2.22 (0.56 - 8.60) | 10.7 (2.76 - 36.8) | 3.31 (1.50 - 7.23) |
| Treatment Success At Or Before 12 months, % (95% CI) | |||||
| Controlled Inflammation - No Activity at 12 months | 81.3 (63.6 - 93.8) | 82.2 (65.4 - 94.0) | 68.7 (57.0 - 80.1) | 89.5 (65.4 - 99.2) | 76. 4 (68.3 - 83.7) |
| Controlled Inflammation - No Activity or Slightly Active at 12 months | 88.9 (70.8 - 98.0) | 80.0 (62.5 - 92.9) | 80.8 (68.5 - 90.5) | 89.0 (64.2 - 99.1) | 83.4 (75.3 - 90.0) |
| Corticosteroid Sparing -Controlled Inflammation and Prednisone ≤ 10 mg/day | 64.8 (46.5 - 82.6) | 60.5 (44.0 - 77.5) | 58.5 (46.8 - 70.6) | 68.9 (43.6 - 90.7) | 61.2 (53.0 - 69.5) |
| Corticosteroid Sparing -Controlled Inflammation and Prednisone ≤ 5 mg/day | 49.1 (32.6 - 68.6) | 37.8 (23.7 - 56.7) | 48.4 (37.0 - 61.2) | 64.6 (40.7 - 87.2) | 47.8 (39.9 - 56.4) |
| Corticosteroid Sparing -Controlled Inflammation and Prednisone = 0 mg/day | 16.2 (7.0 - 34.9) | 15.9 (6.90 - 34.1) | 7.65 (3.49 - 16.3) | 23.5 (9.41 - 51.5) | 12.6 (8.30 - 18.9) |