Table 1.
Molecular mimicry between trigger and target
| Mouse | Target | Trigger | Mimicry | T cell frequency | T cell avidity | Antibody titer | Autoimmune Disease |
|---|---|---|---|---|---|---|---|
| RIP-LCMV | LCMV-GP | LCMV | identical | high | high | n.d | +++ |
| RIP-LCMV | LCMV-NP | LCMV | identical | high | low | n.d | + |
| RIP-LCMV | LCMV-NP | PV | similar | low | n.d. | n.d | - |
| RIP-LCMV | LCMV-NP | LCMV + PV |
identical + similar |
very high | n.d | n.d | +++ |
| FVB | mouse CYP | hCYP2D6 (Ad-2D6) |
similar | high | n.d | very high | +++ |
| hCYP2D6 | mouse CYP + hCYP2D6 |
hCYP2D6 (Ad-2D6) |
similar + identical |
very low | n.d | high | + |
n.d.: not determined