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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Neuroimage. 2009 Dec 21;50(1):7. doi: 10.1016/j.neuroimage.2009.12.053

Figure 1.

Figure 1

The effects of SMI-71 on the integrity of rat blood-brain barrier assessed with Evans blue dye. Note the diffusive distribution of Evans blue dye in SMI-71-treated rat brain (A, right). But the blue stains appear only inside vessels in vehicle-treated rat animal (A, left). B and C show Evans blue distributions in sections grossly dissected (2 mm in thickness) at similar locations. As indicated by the arrows, blue stains are distributed in both the cortical and subcortical structures in SMI-71-treated animal (C); there are minimal blue stains in the vehicle-treated animal (B) except some stains around vessels.