Top panels: pseudo color maps showing the group main effects of ME-MRI signal enhancement (one-way ANOVA, F(2,19)>3.5, p<0.05) following intravenous infusion of SMI-71 (n=10 for the urethane group; n=6 for urethane+isoflurane group) or vehicle (n=6). Of the two groups receiving SMI-71 treatment, the effects of BBB disruption were similar in most structures except in caudate putamen (bottom panels, two-tailed unpaired t-test, t>2.2, p<0.05). Numbers below images are coordinates relative to bregma. Color bars show F and t values, respectively.