Table 1.
Summary of Patient Characteristics and Transplant Outcomes (n=23)
| Variable | Mean ± SD or N(%) |
Median (Range) |
|---|---|---|
| Patient Age at Transplant (Years) | 58 (39 – 69) | |
| Patient Gender | ||
| Female | 12 (52.2) | |
| Male | 11 (47.8) | |
| Donor Gender | ||
| Female | 7 (30.4) | |
| Male | 16 (69.6) | |
| Female Donor to Male Recipient Transplants | 2 (8.7) | |
| Donor Type | ||
| Sibling | 8 (34.8) | |
| Matched Unrelated | 15 (65.2) | |
| Stem Cell Source | ||
| Bone Marrow | 2 (8.7) | |
| Peripheral Blood | 21 (91.3) | |
| CD34 Cell Dose | 7.8 (1.1–20.0) | |
| Time from Diagnosis to Transplant (Months) | 21 (2.0–249.0) | |
| Lille Risk Score at HCT | ||
| Low | 1 (4.4) | |
| Intermediate | 12 (52.1) | |
| High | 10 (43.5) | |
| Time to Engraftment (Days) | ||
| Absolute Neutrophil Count ≥500 | 16.5 (8.0–26.0) | |
| Platelets ≥20 | 18.0 (10.0–110.0) | |
| Transfusion Dependent Post-HCT | ||
| Red Blood Cells | 21 (91.3) | |
| Platelets | 15 (65.2) | |
| GVHD Prophylaxis | ||
| CSA, MMF, +/−MTX | 9 (39.1) | |
| Tacrolimus/Sirolimus, +/−MTX | 14 (60.9) | |
| Acute GVHD | ||
| None | 7 (30.4) | |
| Grade I | 4 (17.4) | |
| II | 7 (30.4) | |
| III | 2 (8.7) | |
| IV | 3 (13.0) | |
| Time to Acute GVHD Onset (Days) | 32 (10–60) | |
| Chronic GVHD | ||
| No | 6 (30.0) | |
| Yes | 14 (70.0) | |
| Limited | 4 (28.6) | |
| Extensive | 10 (43.5) | |
| Died ≤ 100 Days | 3 | |
| Time to Chronic GVHD Onset (Days) | 197 (100–351) | |
| Constitutional Symptoms | ||
| Yes | 2 (8.7) | |
| Fevers only | 1 | |
| Night Sweats only | 1 | |
| No | 21 (91.3) | |
| Relapse post HCT | ||
| Yes | 1 (4.0) | |
| No | 22 (96.0) | |
| Follow-Up (Months) | ||
| All patients | 24.7 (0.7–97.6) | |
| Alive | 29.0 (9.5–97.6) | |
| Dead | 10 (0.7–21.6) | |
| Number of Death Events post HCT | ||
| Alive | 18 (78.3) | |
| Dead | 5 (21.7) | |
| Cause of Death (Transplant Related) |
||
| Yes | 5 (100.00) | |
| No | 0 (0.00) | |
| Cause of Death | ||
| Graft Failure, Sepsis | 1 | |
| GVHD, Sepsis | 1 | |
| GVHD, Sepsis, Graft failure | 1 | |
| Infection | 1 | |
| Respiratory Failure, Alveolar hemorrhage, Renal Failure |
1 | |