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. Author manuscript; available in PMC: 2011 Feb 16.
Published in final edited form as: Brain Res. 2009 Sep 2;1314C:183. doi: 10.1016/j.brainres.2009.08.078

Figure 3.

Figure 3

An intra-PFC infusion of BDNF attenuated extinction responding, cue- and cocaine-induced reinstatement of cocaine-seeking. (A) After 6 days of abstinence, the BDNF-treated rats exhibited significantly fewer active lever presses during the post-abstinence test than the vehicle-treated rats (***P=0.001). (B) The BDNF-treated rats exhibited significantly fewer active (***P<0.001) lever presses during the cue-induced reinstatement test than vehicle-treated rats. (C) The BDNF-treated rats exhibited significantly fewer active lever presses during the cocaine-induced reinstatement test than the vehicle-treated rats (*P<0.05). Modified from Berglind et al., 2007.