Skip to main content
. Author manuscript; available in PMC: 2011 Feb 16.
Published in final edited form as: Brain Res. 2009 Dec 21;1314C:145. doi: 10.1016/j.brainres.2009.12.027

Figure 2.

Figure 2

Effects of N/OFQ on ethanol-reinforced responses in ethanol nondependent (n = 7) and postdependent (right panel: Dependent) Wistar rats (n = 9). Rats self-administered ethanol on a fixed-ratio schedule in 30 min sessions in which each reinforced response resulted in the delivery of 0.1 ml of 10% (w/v) ethanol. A mixed-factorial ANOVA did not reveal significant main effects of ethanol dependence history (F1,14 = 0.6, not significant) or an ethanol dependence history × dose interaction (F3,42 = 0.2, not significant). However, a main effect of dose was detected (F3,42 = 4.0, p < 0.01). Separate one-way ANOVAs revealed a significant effect of N/OFQ in postdependent (F3,24 = 4.2, p < 0.01) but not nondependent rats (F3,18 = 0.9, p = 0.4). For postdependent rats, Newman-Keuls post hoc tests revealed significant differences between vehicle- (0 µg) and N/OFQ-treated rats at all doses tested (*p < 0.05).