Table 2.
Blood spot bile acid concentrations (geometric mean and 95% confidence interval) in cholestatic cases and comparison group
| Group |
Bile acid concentration (μmol/l)
|
Bile acid ratio (95% confidence interval)
|
||||||
|---|---|---|---|---|---|---|---|---|
| GD | GT | TD | TT | TBA | TriOH:DiOH | G:T | ||
| All cases of cholestasis (n=177) | 5.2 (4.4 to 6.0) | 9.7 (8.2 to 11.4) | 4.1 (3.5 to 4.8) | 9.2 (8.1 to 10.4) | 31.0 (28.3 to 35.2) | 2.62 (2.30 to 3.00) | 1.30 (1.16 to 1.44) | |
| Extrahepatic biliary atresia (n=61) | 6.9 (5.6 to 8.4) | 17.9 (14.7 to 21.9) | 4.1 (3.4 to 4.9) | 12.9 (11.2 to 14.8) | 43.0 (37.5 to 0.6) | 3.07 (2.71 to 3.48) | 1.55 (1.36 to 1.74) | |
| Idiopathic neonatal hepatitis (n=52) | 4.3 (3.1 to 6.0) | 7.0 (5.2 to 9.4) | 3.9 (2.7 to 5.5) | 8.0 (6.2 to 10.2) | 25.3 (19.3 to 33.1) | 2.60 (1.94 to 3.35) | 1.15 (0.90 to 1.43) | |
| Alagille syndrome (n=17) | 4.4 (2.2 to 8.0) | 9.6 (5.8 to 15.5) | 4.2 (2.1 to 7.8) | 10.3 (7.3 to 14.2) | 33.0 (21.9 to 49.4) | 3.16 (1.95 to 4.88) | 1.18 (0.70 to 1.79) | |
| α1 Antitrypsin deficiency (n=15) | 6.6 (4.1 to 10.2) | 10.0 (4.8 to 19.9) | 4.5 (2.7 to 7.3) | 9.4 (6.1 to 14.3) | 33.1 (21.2 to 51.2) | 2.03 (1.25 to 3.07) | 1.36 (0.89 to 1.95) | |
| Inherited metabolic disorders (n=10) | 4.9 (0.9 to 17.2) | 4.8 (1.4 to 12.7) | 4.4 (1.1 to 13.1) | 3.5 (1.6 to 6.9) | 22.5 (9.6 to 50.9) | 2.00 (0.23 to 6.29) | 1.50 (0.77 to 2.54) | |
| Comparison group (n=708) | 1.3 (1.2 to 1.4) | 2.5 (2.3 to 2.7) | 1.2 (1.1 to 1.3) | 2.0 (1.8 to 2.1) | 6.9 (6.5 to 7.4) | 2.02 (1.90 to 2.15) | 1.42 (1.33 to 1.52) | |
| 95% Range | 0.0 to 5.8 | 0.0 to 14.9 | 0.0 to 5.11 | 0.0 to 9.5 | 0.0 to 33.3 | 0.00 to 10.57 | 0.00 to 6.75 | |
GD=glycodihydroxycholanoates, GT=glycotrihydroxycholanoates, TD=taurodihydroxycholanoates, TT=taurotrihydroxycholanoates, TBA=total bile acids, TriOH=trihydroxycholanoate conjugates, DiOH=dihydroxycholanoate conjugates, G=glycine conjugates, T=taurine conjugates.