Table 3.
Fold changes in bile acid concentration in cholestasis
| Group | GD | GT | TD | TT | TBA | TriOH:DiOH ratio | G:T ratio |
|---|---|---|---|---|---|---|---|
| Cases of cholestasis (n=177) | 4.0* | 3.9* | 3.4* | 4.6* | 4.5* | 1.3† | 0.9 |
| Extrahepatic biliary atresia (n=61) | 5.3* | 7.2* | 3.4* | 6.5* | 6.2* | 1.5* | 1.1 |
| Idiopathic neonatal hepatitis (n=52) | 3.3* | 2.8* | 3.3* | 4.0* | 3.7* | 1.3 | 0.8 |
| Alagille syndrome (n=17) | 3.5‡ | 3.9* | 3.5‡ | 5.2* | 4.8* | 1.6 | 0.8 |
| α1 Antitrypsin deficiency (n=15) | 5.1* | 4.0‡ | 3.8† | 4.7* | 4.8* | 1.0 | 1.0 |
| Inherited metabolic disorders (n=10) | 3.8 | 1.9 | 3.7 | 1.8 | 3.3‡ | 1.0 | 1.1 |
*
P<0.0001, †=P<0.001, and ‡=P<0.05 compared with comparison group (unpaired t test).
GD=glycodihydroxycholanoates, GT=glycotrihydroxycholanoates, TD=taurodihydroxycholanoates, TT=taurotrihydroxycholanoates, TBA=total bile acids, TriOH=trihydroxycholanoate conjugates, DiOH=dihydroxycholanoate conjugates, G=glycine conjugates, T=taurine conjugates.