FIG. 2.

SS-31 and SS-20 protect dopaminergic neurons in substantia nigra against MPTP damage. (A) Representative slides showed TH-positive neuronal loss in SNpc caused by MPTP toxicity and protected by either SS-31 or SS-20. (B) TH-positive neuronal counts in SNpc showed SS-31 (0.5, 1, and 5 mg/kg) dose-dependently protected neurons from MPTP (10 mg/kg, three doses in 2 h interval) caused cell loss and SS-20 (4 mg/kg) also attained significant protection. (C) Nissl stained neuron counts in SNpc verified the enzyme stained TH-positive neuronal loss. #p < 0.05 compared with normal control. *p < 0.05 compared with MPTP alone, n = 10.