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. Author manuscript; available in PMC: 2010 Dec 9.
Published in final edited form as: J Am Chem Soc. 2009 Dec 9;131(48):17647. doi: 10.1021/ja9073062

Figure 1. Crystal structures of HIF2α PAS-B reveal and internal solvent-filled cavity which binds artificial ligands.

Figure 1

(a). Crystal structure of the PAS B domain of HIF2α in the apo form showing the eight bound solvent atoms within the core of the domain (red spheres). (b). Cutaway of the HIF-2α surface revealing the 290 Å3 internal cavity, depicted as a surface (cyan).