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. Author manuscript; available in PMC: 2010 Dec 9.
Published in final edited form as: J Am Chem Soc. 2009 Dec 9;131(48):17647. doi: 10.1021/ja9073062

Figure 2. HIF2α PAS-B equilibrium ligand-binding thermodynamics.

Figure 2

(a). Typical isothermal titration calorimetry results from compound THS-017 binding to HIF2α PAS-B. (b). Compounds evaluated in this study, shown in wireframe with binding and thermodynamic parameters derived from ITC. (c). The ligand binding pocket of HIF2α PAS-B of the THS-017 (green) and THS-020 (cyan) bound structures. All panels are shown in the same orientation and the ARNT PAS-B* domain heterodimer has been omitted for clarity.