Table 1.

Example of a trial with continuous outcomes with subjects assigned in cohorts of three. The target AGT activity is 5 fmol/mg protein. Data were resampled from Friedman et al. (1998). The new design with Δ = 1 is used.

	Ȳj	t-statistic	Decision
Dose 1, 40 mg/m2
(y11, y12, y13) = (26.35, 42.00, 15.00)	27.78	2.91	Increase the dose to 60 mg/m2
Dose 2, 60 mg/m2
(y21, y22, y23) = (23.00, 13.50, 10.83)	15.78	2.92	Increase the dose to 80 mg/m2
Dose 3, 80 mg/m2
(y31, y32, y33) = (11.70, 9.03, 5.00)	8.58	1.84	Increase the dose to 100 mg/m2
Dose 4, 100 mg/m2
(y41, y42, y43) = (4.07, 5.00, 8.70)	5.92	0.65	Repeat the dose at 100 mg/m2
(y44, y45, y46) = (2.50, 4.07, 6.13)	5.08a	0.09a	Repeat the dose at 100 mg/m2
(y47, y48, y49) = (3.60, 5.00, 5.00)	4.90a	−0.18a	Repeat the dose at 100 mg/m2
(y410, y411) = (6.80, 6.60)	5.22a	0.43a	Repeat the dose at 100 mg/m2

^aCalculated based on the combined sample.