Table 3. Clinical characteristics of pediatric patients with acute wheezing caused by HBoV, rhinovirus, RSV, or mixed virus infections*†.
| Factor | Between groups infected with |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Virus infection |
Single virus
(n = 104) |
Single + mixed (n = 46)‡ |
|||||||
| HBoV (n = 12) | Mixed (n = 34) | Rhinovirus (n = 56) | RSV (n = 36) | p value§ | Adjusted p value¶ | p value§ | |||
| Age, y |
1.4
(0.8–3.2) |
1.3
(0.3–6.1) |
2.2
(0.4–12.5) |
0.9
(0.3–4.5) |
|
<0.0001 |
– |
|
0.57 |
| Male, no. (%) |
9 (75) |
23 (68) |
36 (64) |
20 (56) |
|
0.45 |
0.073 |
|
0.64 |
| At admission | |||||||||
| Severity of illness, scale 0–12 | 7 (4–10) | 7 (2–10) | 6 (2–10) | 7 (4–10) | 0.057 | 0.15 | 0.43 | ||
| % Oxygen saturation | 97 (88–99) | 96 (91–99) | 96 (88–100) | 96 (89–99) | 0.98 | 0.97 | 0.95 | ||
| Temperature, °C | 37.6 (36.1–39.1) | 37.7 (36.2–39.5) | 37.4 (36.2–39.3) | 37.9 (36.3–40.1) | 0.0014 | 0.032 | 0.71 | ||
| CRP, mg/L | 7.50 (0–78) | 10 (0–45) | 18 (0–191) | 8 (0–96) | 0.25 | 0.81 | 0.48 | ||
| Leukocyte count, × 109/L |
8.50
(6.3–11.9) |
11.1
(5.1–23.6) |
12.1
(5.6–20.8) |
9.4
(4.9–20.7) |
|
0.0003 |
<0.0001 |
|
0.029 |
| Duration of hospitalization, h |
30 (18–78) |
27 (6–90) |
18 (6–74) |
38 (6–138) |
|
<0.0001 |
0.0066 |
|
0.12 |
| Duration of cough, d | 15 (4–66) | 11 (2–38) | 8 (1–36) | 11 (4–22) | 0.0022 | 0.020 | 0.062 | ||
| Before admission | 5 (1–60) | 3 (1–28) | 2 (0–19) | 4 (1–14) | <0.0001 | <0.0001 | 0.038 | ||
| After hospitalization | 6 (2–14) | 5 (0–14) | 6 (0–14) | 4 (0–13) | 0.40 | 0.42 | 0.36 | ||
| Moderate–severe after hospitalization |
1 (0–8) |
1 (0–14) |
2 (0–14) |
0 (0–4) |
|
0.019 |
0.0052 |
|
0.34 |
| Duration of breathing difficulty, h | 4 (1–9) | 4 (1–11) | 3 (0–36) | 6 (1–14) | <0.0001 | 0.0047 | 0.48 | ||
| Before admission | 1 (0–7) | 1 (0–7) | 1 (0–19) | 2 (0–6) | 0.040 | 0.67 | 0.63 | ||
| After hospitalization | 0 (0–4) | 1 (0–10) | 0 (0–14) | 3 (0–11) | 0.028 | 0.071 | 0.40 | ||
| Moderate–severe after hospitalization |
0 (0–0) |
0 (0–6) |
0 (0–14) |
0 (0–1) |
|
0.39 |
0.49 |
|
0.13 |
| Other symptoms, no. (%) patients | |||||||||
| Acute otitis media | 4 (33) | 16 (47) | 16 (29) | 26 (72) | 0.0003 | 0.073 | 0.41 | ||
| Nonrespiratory symptoms | |||||||||
| Diarrhea | 1 (8) | 4 (12) | 2 (4) | 7 (19) | 0.072 | 0.21 | 0.74 | ||
| Balance problems | 0 | 1 (3) | 2 (4) | 2 (6) | 0.92 | 0.53 | 0.45 | ||
| Rash | 0 | 0 | 2 (4) | 0 | 1.00 | 1.00 | – | ||
| Arthritis or arthralgia | 0 | 0 | 0 | 0 | – | – | – | ||
*Mixed infections consisted of HBoV plus >1 virus. Values are median (range) except as indicated. HBoV, human bocavirus; RSV, respiratory syncytial virus; CRP, C-reactive protein. †Analysis by regression analysis using generalized linear models after logarithmic transformation for continuous data or by logistic regression analysis for categorical data. Significant intergroup differences were found when persons with HBoV infections were compared with those with other infections: age: HBoV vs. RSV, p = 0.036; leukocyte count: HBoV vs. rhinovirus, p = 0.0009 unadjusted and p = 0.0002 adjusted; duration of hospitalization: HBoV vs. rhinovirus, p = 0.0027 unadjusted and p = 0.0069 adjusted; duration of cough: HBoV vs. rhinovirus, p = 0.0009 unadjusted and p = 0.0012 adjusted; duration of cough before admission: HBoV vs. rhinovirus, p<0.0001 unadjusted and p<0.0001 adjusted and HBoV vs. RSV, p = 0.028 unadjusted and p = 0.019 adjusted; acute otitis media: HBoV vs. RSV, p = 0.0005 unadjusted. ‡A child with 1 PCR-positive nasopharygeal aspirate and a PCR-negative serum sample was classified as having a subacute HBoV infection. In Table 1, he was 1 of 3 nonviremic children with a serodiagnosis for HBoV infection. §Unadjusted. ¶Adjusted for age.