Figure 2.

Structure of KIT and PDGFRA. The location and relative frequencies of GIST-associated kinase mutations are depicted in relation to the structural features of KIT and PDGFRA. The remainder of GIST (about 12% in this series) do not harbor detectable KIT or PDGFRA mutations.

Adapted with permission. © 2004 American Society of Clinical Oncology. All right reserved. Corless CL, Fletcher JA, Heinrich MC. Biology of gastrointestinal stromal tumors. J Clin Oncol. 2004;22(18):3813–3825.³⁰ Adapted with permission. © 2003 American Society of Clinical Oncology. All right reserved. Heinrich MC, Corless CL, Demetri GD, et al. Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol. 2003;21(23):4342–4349.³¹