Table 4.

Mean change analysis of BPI average pain (LOCF approach) for all randomized patients – by disposition status

	Study 1				Study 2
	Placebo		Duloxetine 60/120 mg/day		Placebo		Duloxetine 60/120 mg/day
	n	LS mean change (SE)	n	LS mean change (SE)	n	LS mean change (SE)	n	LS mean change (SE)
	Completers	98	–1.51 (0.20)	84	–2.47 (0.22)***	111	–2.02 (0.17)	92	–3.04 (0.19)***
Discontinuation due to
Adverse events	4	0.85 (1.46)	13	–0.65 (1.06)	7	–0.88 (0.72)	20	–0.93 (0.45)
Lack of efficacy	4	–0.79 (1.44)	3	–0.79 (1.30)	6	–0.36 (0.23)	1	–1.62 (0.54)
Other reasons	9	–1.48 (0.95)	9	–0.49 (0.93)	3	0.07 (1.08)	8	–1.64 (0.69)

^***P ≤ 0.001 versus placebo.

Abbreviations: BPI, Brief Pain Inventory; LOCF, last observation carried forward; LS, least squares; n, number of patients in the specified category; SE, standard error.