Table 2.
Pharmacokinetic parameters after oral administration of CyA-loaded cubic nanoparticles and Sandimmun Neoral® calculated by a noncompartmental method
| Formulation | tmax (h) | Cmax (ng mL−1) | t1/2 (h) | AUC0–t (ng h mL−1) | AUC0–∞ (ng h mL−1) | MRT (h) | Relative bioavailability (%)* |
|---|---|---|---|---|---|---|---|
| Cubic nanoparticles | 2.42 ± 0.80 | 1371.18 ± 357.34 | 12.14 ± 8.37 | 7757.21 ± 1093.64 | 9004.77 ± 1090.38 | 6.56 ± 1.08 | 177.92 ± 47.68 |
| Sandimmun Neoral® | 1.83 ± 0.75 | 969.68 ± 176.30 | 22.29 ± 10.54 | 4739.52 ± 806.30 | 5462.31 ± 990.76 | 6.39 ± 0.70 |
Note:
*
Calculated on AUC0–∞ with Sandimmun Neoral® as reference.