Table 3.
Pharmacokinetic parameters after oral administration of CyA-loaded cubic nanoparticles and Sandimmun Neoral® calculated by a two-compartmental method
| Formulation | ka (h−1) | α (h−1) | β (h−1) | t1/2(α) (h) | t1/2(β) (h) | t1/2(a) (h) | k10 (h−1) | k12 (h−1) | k21 (h−1) |
|---|---|---|---|---|---|---|---|---|---|
| Cubic nanoparticles | 0.52 ± 0.076 | 0.24 ± 0.068 | 0.062 ± 0.056 | 3.05 ± 0.90 | 12.14 ± 8.37 | 1.46 ± 0.37 | 0.096 ± 0.047 | 0.081 ± 0.10 | 0.13 ± 0.10 |
| Sandimmun Neoral® | 0.73 ± 0.37 | 0.41 ± 0.12 | 0.032 ± 0.022 | 1.84 ± 0.57 | 22.29 ± 10.54 | 1.14 ± 0.61 | 0.10 ± 0.054 | 0.19 ± 0.10 | 0.14 ± 0.17 |