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. 2000 Nov-Dec;5(8):463–469. doi: 10.1093/pch/5.8.463

TABLE 2:

Clinical findings related to late congenital syphilis in children older than one year of age

System Findings
Dental (vasculitis due to inflammation of developing tooth buds in late gestation)
  • Hutchinson’s teeth (small widely-spaced, peg-shaped, notched upper incisors with thin discoloured enamel

  • Hypoplastic enamel

  • Mulberry molars (many small cusps)

Ear
  • Sensorineural hearing loss due to osteochondritis of otic capsule and cochlear degeneration

Cutaneous
  • Rhagades (deep fissuring of mucocutaneous junctions in the nares, lips and anus)

Skeletal
  • Frontal bossing, square cranium (skull bone periostitis)

  • Short maxilla, high palatal arch and saddle nose deformity (syphilitic nasal chondritis)

  • Saber shins (anterior tibial bowing)

  • Higoumenaki’s sign (sternoclavicular thickening)

  • Clutton’s joints (painless, symmetric hydrarthrosis of the knees and elbows)

Neurological
  • Mental retardation, hydrocephalus, seizures, cranial nerve palsies, paresis

Ocular
  • Interstitial keratitis

Other organ involvement
  • Renal involvement: paroxysmal cold hemoglobinuria

Hutchinson’s triad
  • Interstitial keratitis

  • Hutchinson’s teeth

  • Sensorineural hearing loss