TABLE 2.
The Most Highly Induced/Repressed Genes Identified by Microarray
| Relative expression | ||||
| Symbol | ITE/DMSO | TCDD/DMSO | ITE/TCDD | Description |
| Aldh3a1 | 735.916 | 611.531 | 1.203 | Aldehyde dehydrogenase family 3, subfamily A1 |
| Cyp1a1 | 538.552 | 577.663 | 0.932 | Cytochrome P450, family 1, subfamily a, polypeptide 1 |
| Megf10 | 150.877 | 146.849 | 1.027 | Multiple EGF-like domains 10 |
| Ahrr | 116.436 | 119.109 | 0.978 | AhR repressor |
| Tac1 | 72.179 | 65.510 | 1.102 | Tachykinin 1 |
| Nsg2 | 66.602 | 62.499 | 1.066 | Neuron-specific gene family, member 2 |
| Tnfrsf19 | 43.960 | 42.908 | 1.025 | Tumor necrosis factor receptor superfamily, member 19 |
| St8sia1 | 41.767 | 50.470 | 0.828 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 |
| Slc1a2 | 37.978 | 37.087 | 1.024 | Solute carrier family 1 (glial high-affinity glutamate transporter), member 2 |
| Slc2a6 | 37.937 | 34.988 | 1.084 | Solute carrier family 2 (facilitated glucose transporter), member 6 |
| Nsg2 | 29.508 | 39.405 | 0.749 | Neuron-specific gene family, member 2 |
| Retn | 28.617 | 26.067 | 1.098 | Resistin |
| Ccnu | 27.563 | 27.670 | 0.996 | Cyclin U |
| Tgfbi | 24.449 | 19.460 | 1.256 | Transforming growth factor, beta induced |
| Nmnat2 | 22.617 | 17.992 | 1.257 | Nicotinamide nucleotide adenylyltransferase 2 |
| Mpp4 | 19.698 | 18.798 | 1.048 | Membrane protein, palmitoylated 4 (MAGUK p55 subfamily, member 4) |
| Tgfbi | 19.584 | 16.833 | 1.163 | Transforming growth factor, beta induced |
| Tiparp | 18.753 | 21.690 | 0.865 | TCDD-inducible poly(ADP-ribose) polymerase |
| St8sia1 | 18.274 | 20.822 | 0.878 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 |
| Nr4a3 | 17.642 | 14.125 | 1.249 | Nuclear receptor subfamily 4, group A, member 3 |
| Rgnef | 16.680 | 17.953 | 0.929 | Rho-guanine nucleotide exchange factor |
| Olfm1 | 16.109 | 15.298 | 1.053 | Olfactomedin 1 |
| Slc1a2 | 16.099 | 13.291 | 1.211 | Solute carrier family 1 (glial high-affinity glutamate transporter), member 2 |
| Slc14a1 | 15.117 | 11.633 | 1.300 | Solute carrier family 14 (urea transporter), member 1 |
| Lrp4 | 14.549 | 13.108 | 1.110 | Low-density lipoprotein receptor–related protein 4 |
| Prss35 | 13.718 | 11.407 | 1.203 | Protease, serine, 35 |
| Tspan33 | 13.631 | 12.905 | 1.056 | Tetraspanin 33 |
| St8sia1 | 12.878 | 20.101 | 0.641 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 |
| Afp | 12.311 | 13.211 | 0.932 | Alpha fetoprotein |
| Nos3 | 9.832 | 12.234 | 0.804 | Nitric oxide synthase 3, endothelial cell |
| Cpox | 9.690 | 10.815 | 0.896 | Coproporphyrinogen oxidase |
| Tiparp | 9.428 | 10.120 | 0.932 | TCDD-inducible poly(ADP-ribose) polymerase |
| Nqo1 | 9.113 | 8.614 | 1.058 | NAD(P)H dehydrogenase, quinone 1 |
| Bmpr1b | 0.268 | 0.210 | 1.279 | Bone morphogenetic protein receptor, type 1B |
| Crct1 | 0.267 | 0.307 | 0.869 | Cysteine-rich C-terminal 1 |
| Kcnh1 | 0.247 | 0.243 | 1.019 | Potassium voltage-gated channel, subfamily H (eag related), member 1 |
| Chst1 | 0.242 | 0.357 | 0.680 | Carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 |
| Fgfr2 | 0.240 | 0.254 | 0.947 | Fibroblast growth factor receptor 2 |
| Edn1 | 0.240 | 0.240 | 1.000 | Endothelin 1 |
| Ivl | 0.227 | 0.207 | 1.097 | Involucrin |
| Ccdc85a | 0.219 | 0.271 | 0.810 | Coiled-coil domain containing 85A |
| Sprr1a | 0.184 | 0.185 | 0.997 | Small proline-rich protein 1A |
| Klhl29 | 0.180 | 0.203 | 0.888 | Kelch-like 29 (Drosophila) |
For all genes shown, q < 5%. Omitted from this list were several probe sets identified only by riken no. or expressed sequence no. and two additional Tgfbi (they are included in the Supplementary table 1).