TABLE 3.

Summary of GSEA

	ITE versus DMSO (DMSO vs. ITE)	TCDD versus DMSO (DMSO vs. TCDD)	ITE versus TCDD (TCDD vs. ITE)
# Gene sets upregulated (downregulated)	676 (766)	714 (728)	524 (918)
# Gene sets significantly enriched at FDR < 25%	13 (0)	9 (0)	0 (0)
# Gene sets enriched at nominal p < 1%	21 (22)	21 (29)	2 (10)

Microarray data were subjected to GSEA as described in “Materials and Methods” section using the three indicated comparisons (ITE vs. DMSO, TCDD vs. DMSO, and ITE vs. TCDD); 21,891 genes (after collapsing the 45,101 array features into gene symbols since many genes are represented by two or more probe sets on the arrays); 1442 gene sets were included in analysis (14–500 genes per set); analyses performed with 1000 iterations.