Table 1.

Cutaneous manifestations of internal malignancies

Cutaneous feature	Clinical findings	Associated malignancy
Acanthosis nigricans (malignant)	Velvety hyperpigmented thickening extending beyond the flexures and neck to involve lips, palms	Intra-abdominal adenocarcinoma, lung carcinoma, lymphoreticular malignancies
Acrokeratosis paraneoplastica (Bazex's syndrome)	Psoriasiform dermatitis with nail dystrophy affecting hands, feet, ears, nose	Squamous cell carcinoma of upper aerodigestive tract
Erythema gyratum repens	Wood grain pattern annular, scaling erythema	Lung carcinoma
Necrolytic migratory erythema	Eroded erythematous annular polycyclic eruption affecting intertriginous areas	Glucagonoma
Sweet syndrome	Plum coloured nodules affecting head, neck and dorsae, hands	Can be associated with leukaemia, lymphoma, multiple myeloma
Pyoderma gangrenosum especially bullous variant	Painful inflammatory ulcers with raised violaceous edge and overhanging borders; associated pathergy	Can be associated with leukaemia, lymphoma, multiple myeloma
Paraneoplastic pemphigus	Bullous, erosive mucosal +/- cutaneous eruption	Haematologic malignancies, thymoma
Necrobiotic xanthogranuloma	Purpuric yellow plaques in periorbital and flexural areas	Monoclonal gammopathy/multiple myeloma
Diffuse plane xanthomas	Yellow-orange macules and plaques	Monoclonal gammopathy/multiple myeloma
Scleromyxoedema	Scleroderma-like thickening of skin associated with coloured skin or erythematous papular infiltrate	Monoclonal gammopathy/multiple myeloma
Primary systemic amyloidosis	Macroglossia, purpura especially periorbital and infiltrated papules	Monoclonal gammopathy/multiple myeloma