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. 2010 Feb 11;5(2):e9176. doi: 10.1371/journal.pone.0009176

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Morine et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Adult female C57 Bl/6 mice were injected intravenously with AAV2/8 LSP.dnMstat and analyzed three months after injection at six months of age (C57 adults). A second group of animals was injected via a subxyphoid approach at postnatal day 3–5 with the same virus and analyzed at 3 months of age (C57 neonates). The fiber area distribution, fiber number and functional properties of the EDL were analyzed in the C57 adults group. (a) In the dnMstat group there was a rightward shift in the fiber size distribution indicative of an increase in fiber area. (b) The number of fibers in the midbelly cross section of the EDL was unchanged. (c-e) There was an increase in cross sectional area (CSA) of the EDL with a proportionate increase in tetanic force resulting in no change in specific force. (f) The fiber type distribution of the soleus was unchanged in the C57 adults group while significantly more type IIB fibers were found in the C57 neonates group. Data represent mean±SD. * Statistically significant compared to control, p<0.05.