Table 3. Estimates of AMD risk from a logistic regression model with terms for smoking, CFH haplotype [6], genotype at ARMS2 A69S (rs10490924) and the risk associated with the CC2/CFB region [8].
| Regression term | OR | 95% C.I. | Significance | |
|---|---|---|---|---|
| Ex-smoker versus never smoker |
2.34 |
1.59 |
3.5 |
<0.001 |
| Current smoker versus never smoker |
5.04 |
2.96 |
8.58 |
<0.001 |
| Number of CFH haplotype 1 |
3.66 |
2.24 |
5.98 |
<0.001 |
| Number of CFH haplotype 2 |
4.5 |
2.85 |
7.09 |
<0.001 |
| Number of CFH haplotype 3 |
2.95 |
1.8 |
4.81 |
<0.001 |
| Number of CFH haplotype 4 |
1.68 |
1.01 |
2.81 |
0.047 |
|
ARMS2 A69S heterozygous |
3.64 |
2.47 |
5.36 |
<0.001 |
|
ARMS2 A69S homozygous |
25.3 |
13.6 |
47.2 |
<0.001 |
|
rs641153
(CFB) |
0.3 |
0.18 |
0.5 |
<0.001 |
|
rs9332739
(CC2) |
0.55 |
0.3 |
1.01 |
0.056 |
|
rs2230199
(C3) |
1.45 |
1.1 |
1.91 |
0.009 |
| Age/year | 1.1 | 1.08 | 1.13 | <0.001 |
Risks associated with smoking are relative to never smokers. CFH haplotypes (1–4; haplotypes 1 and 2 increase risk and are in complete LD with the C risk allele at Y402H while 3 and 4 are non-risk and in complete LD with the T allele at Y402H) are measured against haplotype 5 (the most protective haplotype, which is in complete LD with the deletion at CFHR-3) [6]. ARMS2 is measured on the heterozygosity or homozygosity of the A69S risk allele (rs10490924). rs641153 (CFB), rs9332739 (CC2) and rs2230199 (C3) were coded as 0, 1 or 2 depending on the number of copies of the minor allele present.