Table 3.
Adjusted§ mean percent mammographic density of study population by genotype and haplotype: Group Health, Seattle, WA 2004 – 2005
| Genotype | n (%) | Mean§ (95% CI) | p-value | p trend |
|---|---|---|---|---|
| UGT1A1*28 | ||||
| TA6/TA6 | 91 (52.0) | 39.0 (34.0, 44.1) | Reference | |
| TA6/TA7 | 69 (39.4) | 35.0 (30.0, 39.9) | 0.26 | 0.12 |
| TA7/TA7 | 15 (8.6) | 30.7 (19.7, 41.7) | 0.18 | |
| UGT1A3(W11R) | ||||
| W11/W11 | 68 (38.9) | 40.9 (35.0, 46.9) | Reference | |
| W11/R11 | 74 (42.3) | 35.1 (30.3, 40.0) | 0.14 | 0.04 |
| R11/R11 | 33 (18.9) | 31.6 (24.3, 38.9) | 0.05 | |
| UGT1A3(V47A) | ||||
| V47/V47 | 80 (45.7) | 40.4 (35.0, 45.8) | Reference | |
| V47/A47 | 71 (40.6) | 33.2 (28.4, 37.9) | 0.05 | 0.11 |
| A47/A47 | 24 (13.7) | 34.8 (25.6, 44.1) | 0.30 | |
| UGT2B4(D458E) | ||||
| D458/D458 | 97 (55.4) | 35.0 (30.2, 39.8) | Reference | |
| D458/E458 | 68 (38.9) | 38.2 (33.1, 43.4) | 0.37 | 0.25 |
| E458/E458 | 10 (5.7) | 42.6 (27.0, 58.3) | 0.36 | |
| UGT2B7(H268Y) | ||||
| H268/H268 | 48 (27.4) | 40.4 (33.6, 47.3) | Reference | |
| H268/Y268 | 86 (49.1) | 35.8 (31.0, 40.7) | 0.29 | 0.22 |
| Y268/Y268 | 41 (23.4) | 34.3 (27.3, 41.4) | 0.23 | |
| UGT2B15(D85Y) | ||||
| D85/D85 | 35 (20.0) | 39.4 (33.1, 45.7) | Reference | |
| D85/Y85 | 94 (53.7) | 36.2 (31.6, 40.8) | 0.41 | 0.50 |
| Y85/Y85 | 46 (26.3) | 35.7 (27.9, 43.5) | 0.47 | |
| UGT2B17(deletion) | ||||
| not deleted/not deleted | 73 (41.7) | 38.1 (32.6, 43.6) | Reference | |
| not deleted/deleted | 75 (42.9) | 34.3 (29.3, 39.3) | 0.31 | 0.80 |
| deleted/deleted | 27 (15.4) | 39.6 (29.7, 49.5) | 0.80 | |
| SULT1A1(R213H) | ||||
| R213/R213 | 83 (47.4) | 41.8 (36.5, 47.1) | Reference | |
| R213/H213 | 64 (36.6) | 34.9 (29.6, 40.2) | 0.08 | 0.001 |
| H213/H213 | 28 (16.0) | 25.7 (18.4, 33.0) | 0.001 | |
| Haplotype | Frequency | |||
| UGT1A1(TA6/TA7)- 1A3(W11R)-1A3(V47A) | ||||
| TA6-W11-V47 | 0.59 | 40.6 (33.9, 47.4) | Reference | |
| TA6-R11-V47 | 0.06 | 32.4 (15.6, 49.4) | 0.12 | |
| TA6-R11-A47 | 0.06 | 38.4 (22.5, 54.7) | 0.66 | N/A |
| TA7-R11-A47 | 0.28 | 35.7 (23.8, 47.8) | 0.07 | |
| SULT1E1: rs3775768 (A/G), rs4149530 (G/C) | ||||
| A-G | 0.57 | 37.6 (31.1, 44.2) | Reference | |
| A-C | 0.05 | 38.5 (18.5, 59.0) | 0.87 | N/A |
| G-C | 0.26 | 35.4 (23.9, 47.5) | 0.47 | |
§
adjusted for ethnicity using least squares regression; N/A – not applicable