Table 2.
Crude HR and 95% CI for Traditional PrCa Risk Factors and Diabetes-related Traits in Men From the ARIC Study, United States, 1987–1989 or 1994–1996
Overall (N=6,642) | Whites (N=5,082) | Blacks (N=1,560) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Risk Factor | N | PrCa events | HR | 95% CI | N | PrCa events | HR | 95% CI | N | PrCa events | HR | 95% CI |
Age at baseline (y) | 6,642 | 397 | 1.10d | 1.08, 1.12 | 5,082 | 268 | 1.11d | 1.09, 1.14 | 1,560 | 129 | 1.10d | 1.07, 1.13 |
Race | ||||||||||||
White | 5,082 | 268 | Ref | |||||||||
Black | 1,560 | 129 | 1.72d | 1.40, 2.12 | ||||||||
Family history of PrCaa | ||||||||||||
No | 5,803 | 283 | Ref | 4,082 | 211 | Ref | 1,001 | 72 | Ref | |||
Yes | 374 | 42 | 2.06d | 1.49, 2.85 | 306 | 31 | 2.00d | 1.37, 2.91 | 68 | 11 | 2.34e | 1.24, 4.41 |
Unknown | 1,185b | 72 | 1.69e | 1.31, 2.20 | 694 | 26 | 1.14 | 0.76, 1.71 | 491 | 46 | 1.96d | 1.35, 2.84 |
Prevalent diabetes | ||||||||||||
No | 5,798 | 358 | Ref | 4,559 | 247 | Ref | 1,239 | 111 | Ref | |||
Yes | 792 | 35 | 0.81 | 0.57, 1.14 | 509 | 19 | 0.76 | 0.48, 1.21 | 283 | 16 | 0.72 | 0.42, 1.21 |
Fasting glucose (mmol/L)c | 5,659 | 346 | 0.93 | 0.76, 1.15 | 4,467 | 238 | 1.08 | 0.83, 1.39 | 1,192 | 108 | 0.79 | 0.56, 1.11 |
Fasting insulin (pmol/L)c | 5,659 | 346 | 1.00 | 1.00, 1.00 | 4,467 | 238 | 1.00 | 1.00, 1.00 | 1,192 | 108 | 1.00 | 1.00, 1.00 |
Abbreviations: ARIC, Atherosclerosis Risk in Communities; CI, confidence interval; HR, hazard ratio; PrCa, prostate cancer.
Family history was collected from 1994–1996. Others were collected from 1987–1989.
290 subjects were did not participate in the telephone interview from 1994–1996 and were therefore classified as unknown.
Among men without prevalent diabetes
P<0.001.
P<0.01.