Table 3.
Overall | Whites | Blacks | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | N | PrCa events | HRa, b | 95% CI | N | PrCa events | HRa | 95% CI | N | PrCa events | HRa | 95% CI | P-interaction |
ADRB2 | 6,122 | 365 | 1.04 | 0.89, 1.21 | 4,778 | 253 | 1.06 | 0.89, 1.27 | 1,344 | 112 | --d | --d | 0.43 |
CAPN10 | 6,240 | 380 | 1.20g | 1.00, 1.44 | 4,807 | 257 | 1.29g | 1.05, 1.60 | 1,433 | 123 | 0.95 | 0.67, 1.36 | 0.51 |
CDKAL1 | 6,266 | 379 | 1.01 | 0.87, 1.18 | 4,819 | 256 | 1.01 | 0.84, 1.22 | 1,447 | 123 | 1.01 | 0.79, 1.30 | 0.92 |
CDKN2A/B | 6,304 | 381 | 1.07 | 0.87, 1.33 | 4,856 | 259 | 1.12 | 0.89, 1.42 | 1,448 | 122 | 0.83c | 0.50, 1.37 | 0.24 |
FTO | 6,253 | 379 | 1.04 | 0.91, 1.20 | 4,819 | 256 | 1.11 | 0.94, 1.32 | 1,434 | 123 | 0.91 | 0.71, 1.17 | 0.42 |
HHEX | 6,264 | 382 | 0.96 | 0.82, 1.11 | 4,824 | 258 | 0.94 | 0.79, 1.13 | 1,440 | 124 | 0.99 | 0.73, 1.33 | 0.46 |
IGF2BP2 | 6,234 | 377 | 0.91 | 0.78, 1.06 | 4,816 | 255 | 0.98 | 0.81, 1.18 | 1,418 | 122 | 0.79h | 0.61, 1.02 | 0.53 |
KCNJ11 | 6,209 | 381 | 0.97 | 0.82, 1.15 | 4,795 | 257 | 1.01 | 0.84, 1.20 | 1,414 | 124 | --d | --d | 0.06 |
PPARG | 6,211 | 374 | 0.93c | 0.70, 1.22 | 4,731 | 248 | 0.94c | 0.70, 1.26 | 1,480 | 126 | 0.84c | 0.37, 1.90 | 0.81 |
SLC2A2 | 6,279 | 384 | 0.85h | 0.72, 1.00 | 4,859 | 262 | 0.76g | 0.60, 0.94 | 1,420 | 122 | 0.97 | 0.76, 1.24 | 0.38 |
SLC30A8 | 6,224 | 374 | 0.97 | 0.82, 1.16 | 4,820 | 255 | 1.01 | 0.84, 1.21 | 1,404 | 119 | 0.77c | 0.50, 1.20 | 0.27 |
TCF7L2e | 6,215 | 379 | 0.88 | 0.75, 1.03 | 4,770 | 256 | 0.87 | 0.72, 1.06 | 1,445 | 123 | 0.89 | 0.67, 1.18 | 0.30 |
UCP2 | 6,235 | 379 | 0.84g | 0.73, 0.97 | 4,827 | 258 | 0.84g | 0.70, 0.99 | 1,408 | 121 | 0.85 | 0.66, 1.10 | 0.22 |
Abbreviations: ARIC, Atherosclerosis Risk in Communities; CI, confidence interval; HR, hazard ratio; PrCa, prostate cancer; SNP, single nucleotide polymorphism.
For additive genotypic model (i.e., 0, 1, or 2 diabetes risk-raising alleles) unless otherwise noted.
Adjusted for race; effect sizes were similar after additional adjustment for age (y), family history (yes, no, unknown), and prevalent diabetes except for the PPARG SNP in blacks (fully-adjusted HR=0.97, 95% CI=0.39, 2.37).
Comparing two copies of risk allele to less than two copies due to low frequency of non-risk homozygotes.
Estimates not reported since they were based on less than 5 cases homozygous for the diabetes risk-raising allele.
Under a dominant model: overall HR=0.79, 95% CI= 0.65, 0.97, P=0.03; whites HR=0.78, 95% CI=0.61, 0.99, P =0.04; blacks HR=0.83, 95% CI=0.59, 1.19, P=0.32.
P<0.01.
P<0.05.
P<0.1.