Skip to main content
. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2010 Feb;19(2):558. doi: 10.1158/1055-9965.EPI-09-0902

Table 3.

Race-adjusted and Race-specific HR and 95% CI for Diabetes SNPs and Incident PrCa in ARIC Study Men, United States, 1987–2000

Overall Whites Blacks
Gene N PrCa events HRa, b 95% CI N PrCa events HRa 95% CI N PrCa events HRa 95% CI P-interaction
ADRB2 6,122 365 1.04 0.89, 1.21 4,778 253 1.06 0.89, 1.27 1,344 112 --d --d 0.43
CAPN10 6,240 380 1.20g 1.00, 1.44 4,807 257 1.29g 1.05, 1.60 1,433 123 0.95 0.67, 1.36 0.51
CDKAL1 6,266 379 1.01 0.87, 1.18 4,819 256 1.01 0.84, 1.22 1,447 123 1.01 0.79, 1.30 0.92
CDKN2A/B 6,304 381 1.07 0.87, 1.33 4,856 259 1.12 0.89, 1.42 1,448 122 0.83c 0.50, 1.37 0.24
FTO 6,253 379 1.04 0.91, 1.20 4,819 256 1.11 0.94, 1.32 1,434 123 0.91 0.71, 1.17 0.42
HHEX 6,264 382 0.96 0.82, 1.11 4,824 258 0.94 0.79, 1.13 1,440 124 0.99 0.73, 1.33 0.46
IGF2BP2 6,234 377 0.91 0.78, 1.06 4,816 255 0.98 0.81, 1.18 1,418 122 0.79h 0.61, 1.02 0.53
KCNJ11 6,209 381 0.97 0.82, 1.15 4,795 257 1.01 0.84, 1.20 1,414 124 --d --d 0.06
PPARG 6,211 374 0.93c 0.70, 1.22 4,731 248 0.94c 0.70, 1.26 1,480 126 0.84c 0.37, 1.90 0.81
SLC2A2 6,279 384 0.85h 0.72, 1.00 4,859 262 0.76g 0.60, 0.94 1,420 122 0.97 0.76, 1.24 0.38
SLC30A8 6,224 374 0.97 0.82, 1.16 4,820 255 1.01 0.84, 1.21 1,404 119 0.77c 0.50, 1.20 0.27
TCF7L2e 6,215 379 0.88 0.75, 1.03 4,770 256 0.87 0.72, 1.06 1,445 123 0.89 0.67, 1.18 0.30
UCP2 6,235 379 0.84g 0.73, 0.97 4,827 258 0.84g 0.70, 0.99 1,408 121 0.85 0.66, 1.10 0.22

Abbreviations: ARIC, Atherosclerosis Risk in Communities; CI, confidence interval; HR, hazard ratio; PrCa, prostate cancer; SNP, single nucleotide polymorphism.

a

For additive genotypic model (i.e., 0, 1, or 2 diabetes risk-raising alleles) unless otherwise noted.

b

Adjusted for race; effect sizes were similar after additional adjustment for age (y), family history (yes, no, unknown), and prevalent diabetes except for the PPARG SNP in blacks (fully-adjusted HR=0.97, 95% CI=0.39, 2.37).

c

Comparing two copies of risk allele to less than two copies due to low frequency of non-risk homozygotes.

d

Estimates not reported since they were based on less than 5 cases homozygous for the diabetes risk-raising allele.

e

Under a dominant model: overall HR=0.79, 95% CI= 0.65, 0.97, P=0.03; whites HR=0.78, 95% CI=0.61, 0.99, P =0.04; blacks HR=0.83, 95% CI=0.59, 1.19, P=0.32.

f

P<0.01.

g

P<0.05.

h

P<0.1.