Table 4.

Multivariable Analysis of Diabetes, Diabetes SNPs and Traditional PrCa Risk Factors in ARIC Study Men, United States, 1987–2000

	Overall		Whites		Blacks
Risk Factor	HRa	95% CI	HRa	95% CI	HRa	95% CI
CAPN10 (rs3792267)b	1.20g	0.99, 1.44	1.28f	1.03, 1.58	0.95	0.65, 1.39
SLC2A2 (rs5400)b	0.85g	0.71, 1.01	0.75f	0.60, 0.95	0.98	0.76, 1.27
TCF7L2 (rs7903146)c	0.84	0.68, 1.03	0.81	0.63, 1.04	0.90	0.62, 1.30
UCP2 (rs660339)b	0.83f	0.72, 0.96	0.82f	0.69, 0.98	0.85	0.65, 1.10
Age (y)	1.11d	1.09, 1.13	1.12d	1.09, 1.15	1.09d	1.06, 1.13
Black race	1.75d	1.35, 2.28
Family history of PrCa
No	Ref		Ref		Ref
Yes	1.94d	1.39, 2.72	1.78e	1.20, 2.65	2.53e	1.33, 4.81
Unknown	1.32g	1.00, 1.76	1.06	0.69, 1.62	1.70	1.13, 2.52
Prevalent Diabetes	0.62f	0.43, 0.89	0.63g	0.38, 1.03	0.64	0.36, 1.12

Abbreviations: ARIC, Atherosclerosis Risk in Communities; CI, confidence interval; HR, hazard ratio; PrCa, prostate cancer; SNP, single nucleotide polymorphism.

^aEach factor is adjusted for all other factors listed in a multivariable model.

^bUsing an additive genetic model (i.e., 0, 1, or 2 diabetes risk-raising alleles).

^cUnder a dominant genetic model (i.e., 0 or ≥1 diabetes risk-raising alleles).

^dP<0.001.

^eP<0.01.

^fP<0.05.

^gP<0.1.