. Author manuscript; available in PMC: 2010 Feb 10.

Published in final edited form as: Mult Scler. 2010 Feb;16(2):166. doi: 10.1177/1352458509353649

Table 3.

Univariate correlation coefficients of disability scores with age and callosal MRI indices; in parentheses, the corresponding p-values for both fixed-effects (baseline data) and mixed-effects (all data) models. For the MSFC and its components, z-scores, constructed so that lower values correspond to greater disability, were used. As there were 5 disability scores tested, p<0.01 for the mixed-effects model denotes significance (boldface).

	EDSS	MSFC (z-scores)
	EDSS	combined score	25-foot walk	9-hole peg test	PASAT-3
*age*	0.51 (<0.001; <0.001)	−0.20 (0.14; 0.04)	−0.18 (0.21; 0.09)	−0.19 (0.17; 0.04)	−0.12 (0.40; 0.21)
*callosal FA*	−0.14 (0.29; 0.21)	0.27 (0.05; 0.004)	0.14 (0.31; 0.11)	0.31 (0.02; 0.001)	0.35 (0.01; <0.001)
*callosal MD*	0.18 (0.19; 0.35)	−0.29 (0.04; 0.003)	−0.21 (0.13; 0.04)	−0.31 (0.02; 0.006)	−0.23 (0.10; 0.006)
*callosal λ_\|\|*	0.16 (0.26; 0.90)	−0.13 (0.35; 0.12)	−0.13 (0.34; 0.15)	−0.13 (0.36; 0.49)	−0.02 (0.91; 0.36)
*callosal λ_⊥*	0.18 (0.19; 0.28)	−0.29 (0.04; 0.004)	−0.18 (0.19; 0.08)	−0.31 (0.02; 0.003)	−0.30 (0.03; 0.001)
*callosal MTR*	−0.12 (0.42; 0.91)	0.06 (0.67; 0.56)	−0.05 (0.75; 0.74)	0.17 (0.24; 0.25)	0.21 (0.14; 0.009)

Abbreviations: FA, fractional anisotropy. MD, mean diffusivity. λ_⊥, perpendicular diffusivity. EDSS, expanded disability status score. PASAT-3, paced auditory serial addition task, 3 second version.