Table 5.

Relative risk (95% CI) of advanced prostate cancer associated with tertiles of acid-labile subunit and total IGF1 (A), free IGF1 (B) or IGFBP3 (C), cross-classified, Physicians’ Health Study, 1982–1995.

Table 5A. P for interaction = 0.10
		Total IGF1 (tertiles) N Exposed Cases/RR (95% CI)
Acid labile subunit (tertiles)		Low	Medium	High
	Low	26	11	8
		REF	1.5 (0.5–4.7)	9.3 (1.7–51.3)
	Medium	15	17	23
		4.0 (1.1–14.0)	2.6 (0.9–7.5)	6.0 (1.9–18.9)
	High	10	28	22
		3.1 (0.9–10.8)	6.6 (2.1–20.4)	5.0 (1.5–16.1)
Data are adjusted for age, smoking, height, body mass index, and IGFBP3 using conditional logistic regression

Table 5B. P for interaction = 0.29
		Free IGF1 (tertiles) Exposed Cases/RR (95% CI)
Acid labile subunit (tertiles)		Low	Medium	High
	Low	21	14	8
		REF	1.4 (0.5–3.9)	3.3 (0.7–15.4)
	Medium	17	18	19
		4.1 (1.3–13.5)	2.7 (0.9–8.5)	3.3 (1.0–10.5)
	High	11	20	29
		3.8 (1.1–13.3)	7.1 (2.1–24.2)	3.2 (1.1–9.2)
Data are adjusted for age, smoking, height, body mass index, and IGFBP3 using conditional logistic regression

Table 5C. P for interaction = 0.84
		IGFBP3 (tertiles) N Exposed Cases/RR (95% CI)
Acid labile subunit (tertiles)		Low	Medium	High
	Low	32	10	3
		REF	0.8 (0.2–2.6)	0.4 (0.1–2.9)
	Medium	14	30	11
		1.8 (0.6–5.3)	1.6 (0.6–4.1)	0.5 (0.1–1.5)
	High	8	22	30
		6.1 (1.2–30.1)	2.0 (0.7–5.7)	0.7 (0.3–1.6)
Data are adjusted for age, smoking, height, body mass index, and total IGF1 using conditional logistic regression