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. Author manuscript; available in PMC: 2011 Feb 15.
Published in final edited form as: Cancer. 2010 Feb 15;116(4 Suppl):1067–1074. doi: 10.1002/cncr.24794

Figure 3.

Figure 3

Influence of external radiation and proteasome inhibitor MG-132 on CasKi cell death in vitro and on tumor uptake and biodistribution of 188Re-C1P5 mAb in vivo: a) number of dead cells post radiation exposure; b) 24 hr uptake of 188Re-C1P5 mAb in CasKi tumors in mice exposed to 6 Gy external radiation and given 188Re-C1P5 mAb 3 days later; c) number of dead cells post MG-132 treatment; d) 24 hr uptake of 188Re-C1P5 mAb in CasKi tumors in mice treated with 20 μg MG-132 radiation and given 188Re-C1P5 mAb 3 hrs later; e) organ uptake of 188Re-C1P5 mAb in untreated and MG-132-treated CasKi tumor bearing mice. Pre-treatment of tumors with MG132 promotes the uptake of 188Re-C1P5 mAb while external radiation does not.