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AAV–NPY transduction in the hippocampus. Photomicrographs of coronal hippocampal sections of aged rats showing FIB–NPY 13–36 mRNA (right panel) was present in the NPY group, and the absence of specific probe hybridization in the brain of a control rat (left panel). In testing for the FIB–NPY in situ probe, we also generated and hybridized a sense control probe. This control probe showed very little signal as expected (not shown). DG, dentate gyrus.
