Fig 3. Adenosine A2A receptor antagonist SCH58261 counteracts astroglia activation in the SNc and Str.
(A) shows representative sections immunostained for GFAP, from SNc (upper images) and Str (lower images) of mice sacrificed 3 days after MPTP treatment. Mice were treated as described in Fig 1. (B) shows analysis of GFAP immunostaining 1, 3, 7 days after MPTP, reported as percentage of GFAP-positive cells as compared to vehicle-treated mice in the SNc (left graph) and in the Str (right graph). * indicates p<0.001 versus corresponding vehicle and MPTP+SCH58261 groups; # indicates p<0.001 versus corresponding MPTP group, by Tukey’s post hoc test. Scale bar: 50 μm.