Table 2.
Examples of Informative ASM-Associated SNPs Located Near Known Imprinted Loci
| Location | SNP ID | Average RAS Change | Nearest Gene(s) | Known Imprinted Genes in Region |
|---|---|---|---|---|
| 2p12 | SNP_A-8486811 (rs11883960) | 0.24 | CTNNA2a- LRRTM1 | LRRTM1 |
| 6q25.3 | SNP_A-2187171 (rs539958) | 0.11 | SLC22A3b | IGF2R, SLC22A2, SLC22A3 |
| 7p12.2 | SNP_A-8615031 (rs12719019) | 0.14 | IKZF1a | DDC, GRB10 |
| 7q21.3 | SNP_A-2262372 (rs1029391) | 0.17 | SLC25A13a | PPP1R9A |
| 11p15.4 | SNP_A-4258853 (rs4758622) | 0.34 | NAP1L4c | H19, IGF2, IGF2AS, INS, KCNQ1, KCNQ10T1, KCNQ1DN, CDKN1C, SLC22A18, PHLDA2, OSBPL5 |
| 11p15.5 | SNP_A-4301486 (rs2107425) | 0.17 | H19 | H19, IGF2, IGF2AS, INS, KCNQ1, KCNQ10T1, KCNQ1DN, CDKN1C, SLC22A18, PHLDA2, OSBPL5 |
| SNP_A-8447191 (rs2735971) | 0.10 | |||
| SNP_A-8613640 (rs4930101) | 0.21 | |||
| SNP_A-8608669 (rs12417375) | 0.19 | |||
| SNP_A-8654762 (rs2735469) | 0.18 | |||
| 11p15.5 | SNP_A-8632218 (rs10840442) | 0.11 | INS-IGF2 | H19, IGF2, IGF2AS, INS, KCNQ1, KCNQ10T1, KCNQ1DN, CDKN1C, SLC22A18, PHLDA2, OSBPL5 |
| 14q32.2 | SNP_A-8638885 (rs10148112) | 0.33 | EML1a | DLK1, GTL2, RTL1 |
| 14q32.31 | SNP_A-8303781 (rs1889364) | 0.15 | DIO3c | DLK1, GTL2, RTL1 |
| 14q32.31 | SNP_A-8417055 (rs10431745) | 0.18 | PPP2R5Ca | DLK1, GTL2, RTL1 |
| 15q11.2 | SNP_A-1932077 (rs220030) | 0.34 | SNURF-SNRPN | MKRN3, MAGEL2, NDN, PWRN1, C15ORF2, SNURF-SNRPN, UBE3A, ATP10A |
| 19q13.41 | SNP_A-8392857 (rs8105870) | 0.22 | ZNF331 | ZNF331 |
| SNP_A-8655708 (rs7248353) | 0.20 | |||
| 19q13.43 | SNP_A-8306238 (rs10412302) | 0.15 | MIMT1, ZIM2-PEG3 | MIMT1, ZIM2, PEG3 |
| 20q13.32 | SNP_A-8660497 (rs3761263) | 0.17 | GNAS | GNAS |
a
Imprinting status unknown.
b
Previously shown to exhibit only temporary imprinting, with monoallelic expression limited to the first-trimester placenta.
c
Known to be imprinted in mouse, but status in humans is unknown.