Fig. 1.

Paw swelling score in CAIA and CAIA + SRL mice. Arthritis was induced in mice by ip injection of anti-type II collagen monoclonal antibody (mAb) and lipopolysaccharide (LPS). The day of LPS injection was defined as day 0 of arthritis. Each group of mice was started on its specified diet 8 days prior to LPS injection. Paw swelling was measured from day 0 to day 14. Paw swelling score was calculated by micro caliper and visual analog scale. Values are the means ± SD (n = 6). *P < 0.05 versus CAIA