Table 2.
Ongoing clinical trials involving curcumin in patients affected by cancer
| Status | Trial name | Disease | Treatment applied | Clinical phase study |
|---|---|---|---|---|
| Active, not recruiting | Curcumin (diferuloylmethane derivative) with or without bioperine in patients with multiple myeloma | Multiple myeloma | Curcumin; bioperine | nd |
| Recruiting | Curcumin with pre-operative capecitabine and radiation therapy followed by surgery for rectal cancer | Rectal cancer | Radiation: radiotherapy; capecitabine; curcumin; placebo | Phase II |
| Recruiting | Curcumin for prevention of oral mucositis in children chemotherapy | Chemotherapy induced mucositis | Curcumin liquid extract | Phase III |
| Completed | Pharmacokinetics of curcumin in healthy volunteers | Healthy | Curcumin | nd |
| Active, not recruiting | Trial of curcumin in advanced pancreatic cancer | Adenocarcinoma; pancreatic neoplasms | Curcumin | Phase II |
| Active, not recruiting | Curcumin in preventing colon cancer in smokers with aberrant crypt foci | Colorectal cancer; precancerous/nonmalignant condition | Dietary supplement: curcumin | Phase II |
| Not yet recruiting | Bio-availability of a new liquid tumeric extract | Healthy | Liquid tumeric/curcumin extract | Phase I |
| Recruiting | Pilot study of curcumin formulation and Ashwagandha extract in advanced osteosarcoma | Osteosarcoma | Dietary supplement: curcumin powder, Ashwagandha extract | Phase I and II |
| Recruiting | Gemcitabine with curcumin for pancreatic cancer | Pancreatic cancer | Curcumin (+gemcitabine) | Phase II |
| Not yet recruiting | Phase III trial of gemcitabine, curcumin and celebrex in patients with metastatic colon cancer | Colon Neoplasm | Celecoxib; curcumin | Phase III |
| Suspended | Curcumin for treatment of intestinal adenomas in familial adenomatous polyposis (FAP) | Familial adenomatous polyposis | Dietary supplement: curcumin; dietary supplement: placebo | Phase II |
| Recruiting | Curcumin for treatment of intestinal adenomas in familial adenomatous polyposis (FAP) | Familial adenomatous polyposis | Curcumin | nd |
| Terminated | Use of curcumin in the lower gastrointestinal tract in familial adenomatous polyposis patients | Familial adenomatous polyposis | Curcumin | Phase II |
| Recruiting | Phase III Trial of Gemcitabine, Curcumin and Celebrex in patients with advance or inoperable pancreatic cancer | Pancreatic cancer | Gemcitabine; Curcumin; Celebrex | Phase III |
| Completed | Curcumin for the prevention of colon cancer | Colorectal cancer | Dietary supplement: curcumin | Phase I |
| Completed | The effects of curcuminoids on aberrant crypt foci in the human colon | Aberrant crypt foci | Sulindac; curcumin | nd |
| Not yet recruiting | A nutritional supplement capsule containing curcumin, green tea extract, polygonum cuspidatum extract, and soybean extract in healthy participants | Healthy, no evidence of disease | Dietary supplement: curcumin/green tea extract/Polygonum cuspidatum extract/soybean extract capsule | nd |
| Suspended | Sulindac and plant compounds in preventing colon cancer | Colorectal cancer | Dietary supplement: curcumin, rutin Drug: quercetin, sulindac |
nd |
| Recruiting | Curcumin for the chemoprevention of colorectal cancer | Adenomatous polyps | Curcuminoids | Phase II |
| Recruiting | Effect of oral curcumin on Heme-1 (HO-1) in healthy male subjects | Healthy | Dietary supplement: curcumin | Phase I |
The table was generated by using the registry of federally and privately supported clinical trials conducted in the United States and around the world (http://clinicaltrials.gov)
nd non-defined