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ABC transporter localisation in gut epithelial cells. P-glycoprotein (Pgp/MDR1), MRP2 and BCRP are localised in the apical membrane, effluxing compounds back in to the gut lumen; whereas MRP1, 3 and 5 are localised in the basolateral membranes pumping substrates in to the blood stream. MRP4 is present in both the apical and basolateral membranes of gut epithelia [6]
