Figure 1. Survival times of Nrf2^+/+ and Nrf2^−/− mice infected with P. aeruginosa following hyperoxic insult.

Nrf2^+/+ and Nrf2^−/− mice (n = 12/genotype) were exposed to room air or hyperoxia for 48 h and then infected with 10⁶ cfu P. aeruginosa. Mice were allowed to recover under normoxic condition (room air). The survival times of mice were monitored every 6–12 h thereafter for several days as indicated. *P ≤ 0.05 vs. room air control of the same genotype (n=5); † P ≤ 0.05, Nrf2^−/− mice vs. Nrf2^+/+ mice subjected to hyperoxia.