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. Author manuscript; available in PMC: 2010 Feb 11.
Published in final edited form as: Am J Physiol Renal Physiol. 2007 Aug 8;293(4):F1332–F1341. doi: 10.1152/ajprenal.00319.2007

Fig. 4.

Fig. 4

Plasma elimination of p-aminohippurate (PAH) in male Oat3(−/−) and wild-type mice in the presence or absence of probenecid. [3H]PAH and [14C]inulin were concomitantly administered by intravenous injection in the presence or absence of probenecid (~1 mM in plasma via HPLC) that was administered intraperitoneally 15 min before injection. Plasma levels were determined by scintillation counting at 1, 5, 10, 15, 20, and 30 min. A: plasma elimination profile of PAH. B: plasma elimination profile of inulin. Values are means ± SE; n = 3–7. Squares, no inhibition; diamonds, inhibition; open symbols, Oat3(−/−); closed symbols, wild-type. Significance was assessed between genotypes given the same treatment by ANOVA (***P < 0.001).