Figure 3.
A scheme that produces either crossover or non-crossover recombinants from single or double Holliday junctions. Resection of a DSB produces two 3′ single strand overhangs, one of which invades a homologous duplex, producing a D-loop. A single HJ results if this D-loop is cut before second end capture (left). A double HJ results if the D-loop remains uncut before second end capture (right). In both cases resolution of the HJ(s) results in crossover or non-crossover products, depending on the strands cleaved.