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. Author manuscript; available in PMC: 2010 Feb 15.
Published in final edited form as: J Infect Dis. 2009 Aug 15;200(4):555–563. doi: 10.1086/603541

Figure 4.

Figure 4

Association of Streptococcus pyogenes cell envelope proteinase (SpyCEP) activity with disease outcome. A, SpyCEP activity was measured in the culture supernatant of clinical invasive S. pyogenes disease isolates by means of enzyme-linked immunosorbent assay (ELISA) performed to calculate interleukin(IL)-8 degrading activity as a percentage of the control, averaged over 3 separate experiments. Isolates were matched to the disease outcome of the patient from which they originated (survivors or non-survivors). The median value of the data is denoted by a horizontal line. SpyCEP activity was significantly higher in strains from non-survivors (P< 0.016, Mann-Whitney U test). B, Association of patient serum IL-6 levels with the SpyCEP activity of the causative isolate. IL-6 was measured by ELISA performed on patient serum samples obtained at the onset of bacteremia. High IL-6 levels were associated with high SpyCEP activity apparent at SpyCEP activity >90% (dotted line).