Table 3.
Mutations of the TP53, PI3K, and RB1 pathways in GBM samples. Mut, mutated; Amp, amplified; Del, deleted; Alt, altered.
| TP53 pathway |
PI3K pathway |
RB1 pathway |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tumor sample |
TP53 | MDM2 | MDM4 | All genes |
PTEN | PIK3CA | PIK3R1 | IRS1 | All genes |
RB1 | CDK4 | CDKN2A | All genes |
| Br02X | Del | Alt | Mut | Alt | Del | Alt | |||||||
| Br03X | Mut | Alt | Mut | Alt | |||||||||
| Br04X | Mut | Alt | Mut | Alt | Mut | Alt | |||||||
| Br05X | Amp | Alt | Mut | Alt | Del | Alt | |||||||
| Br06X | Del | Alt | |||||||||||
| Br07X | Mut | Alt | Mut | Alt | Del | Alt | |||||||
| Br08X | Del | Alt | |||||||||||
| Br09P | Mut | Alt | Amp | Alt | |||||||||
| Br10P | Mut | Alt | |||||||||||
| Br11P | Mut | Alt | |||||||||||
| Br12P | Mut | Alt | Mut | Alt | |||||||||
| Br13X | Mut | Alt | Del | Alt | |||||||||
| Br14X | Mut | Alt | Del | Alt | |||||||||
| Br15X | Mut | Del | Alt | ||||||||||
| Br16X | Amp | Alt | Amp | Alt | |||||||||
| Br17X | Mut | Alt | Del | Alt | |||||||||
| Br20P | |||||||||||||
| Br23X | Mut | Alt | Del | Alt | |||||||||
| Br25X | Mut | Alt | Del | Alt | |||||||||
| Br26X | Mut | Alt | Del | Alt | |||||||||
| Br27P | Mut | Alt | Amp | Alt | |||||||||
| Br29P | Mut | Alt | |||||||||||
| Fraction of tumors with altered gene/pathway* | 0.55 | 0.05 | 0.05 | 0.64 | 0.27 | 0.09 | 0.09 | 0.05 | 0.50 | 0.14 | 0.14 | 0.45 | 0.68 |
*
Fraction of affected tumors in 22 Discovery Screen samples.