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. Author manuscript; available in PMC: 2010 Feb 11.
Published in final edited form as: J Immunol. 2009 May 1;182(9):5363. doi: 10.4049/jimmunol.0803980

Figure 8.

Figure 8

Presence of natural antibodies to annexin IV. A, Cr2+/+ in contrast to Cr2−/− mice demonstrate higher levels of IgM natural Ab to annexin IV. Serum samples from three cohorts of mice, Cr2−/− (n=9), Cr2+/+ mice (n=14) and negative control Rag1−/− (n=5) mice were evaluated for the presence of natural IgM (left) and IgG (right) Abs to bacterial annexin IV. The figures are representative of two independent experiments. Statistical significance was determined using a Wilcoxson test. B, 9 serum samples from healthy humans and three from agammaglobulinemic patients were tested in the anti-annexin IV ELISA. Substantial levels of anti-annexin IV IgM antibody IgM is present in the sera of normal humans.