(A) Total body weight on regular (RD) or high fat (HFD) diet. Obesity is induced by HFD starting immediately after weaning at 3 weeks of age.
(B) Analysis of body fat by dual energy X-ray absorptiometry (DEXA).
(C and D) Serum leptin (C) and adiponectin (D) levels after 6 hours daytime food withdrawal in Pkr+/+ (n = 5) and Pkr−/− (n = 6) mice on HFD for 15 weeks.
(E and F) Blood glucose (E) and serum insulin (F) levels after 6 hours daytime food withdrawal in Pkr+/+ (n = 6) and Pkr−/− (n = 6) mice on HFD for 8 weeks.
(G) Glucose tolerance tests were performed on Pkr+/+ (n = 6) and Pkr−/− mice (n = 6) on RD and HFD for 6 weeks.
See also Supplemental Figure S4.