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. Author manuscript; available in PMC: 2011 Feb 5.
Published in final edited form as: Cell. 2010 Feb 5;140(3):338. doi: 10.1016/j.cell.2010.01.001

Figure 6. PKR mediates lipid-induced insulin resistance.

Figure 6

(A–F) Hyperinsulinaemic–euglycaemic clamp studies performed in Pkr+/+ (n = 5) and Pkr−/− mice (n = 5) infused with lipid for 5 hours. Glucose infusion rates (GIR) throughout the clamp procedure (A). Average GIR (B). Whole body glucose disposal rates (Rd) (C). Hepatic glucose production (HGP) during the clamp (D). Tissue glucose uptake in gastrocnemius muscle (E) and epididymal fat (F) tissues of Pkr+/+ and Pkr−/− mice. Data are shown as the mean ± SEM.

See also Supplemental Figure S6.