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. 2010 Jan 11;10:10. doi: 10.1186/1471-2407-10-10

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Copyright ©2010 Dickerson et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of increasing concentrations of docetaxel on SK-OV-3 cells treated with siRNA-loaded nanogels. A. Effects of docetaxel on SK-OV-3 cells were tested alone or in combination with EGFR siRNA-loaded, YSA-targeted nanogels. The percent cytotoxicity (Tox 8 assay) was assessed at increasing concentrations of docetaxel and compared to untreated controls. B. Chemosensitization of SK-OV-3 cells treated with the highest dose of siRNA-loaded nanogels and increasing concentrations of docetaxel were compared to several controls. Controls included unloaded YSA-conjugated nanogels (YSA-pNIPMAm), unloaded pNIPMAm nanogels (pNIPMAm), YSA peptide alone, and untreated cells. Results are the mean of two independent experiments; error bars represent standard deviation. Chemosensitivity of nanogel treated SK-OV-3 cells did not differ significantly from all the controls examined (P > 0.05) at all doses of docetaxel.