Table 5.

Analysis of the TMACC interpretation of the DHFR data set.

	Activity
DHFR inhibitor feature	Negative	Neutral	Positive
2-amino nitrogen	155	81	161
4-amino nitrogen	110	61	212
N1-nitrogen	307	58	32
C8 Quinazoline	0	5	45
N8 Pyrido [2,3-d]pyrimidine	68	16	11
5-methyl	1	0	64
9-methyl	0	1	16
10-methyl	10	3	57
Benzylmethoxy - methyl	5	6	392

Table shows frequency of activity of DHFR inhibitor features as determined by the TMACC interpretation