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. Author manuscript; available in PMC: 2010 Feb 11.
Published in final edited form as: Curr Opin Neurobiol. 2007 Feb 1;17(1):43. doi: 10.1016/j.conb.2007.01.011

Table 1.

Selectivity of −S4 β-neurexins and +B neuroligin for glutamatergic synapses, and +S4 β-neurexins and −B neuroligins for GABAergic synapses

A. Effect of splicing on relative binding affinitiesa
graphic file with name nihms-174467-t0003.jpg
B. Induction of postsynaptic protein clustering by +S4 neurexin 1β in co-culture assaysb
Proteins: Neuroligin 1/3/4 Neuroligin 2 PSD-95 Gephyrin
Clustering (%): 65c 90c 50c, 7d 104c, 110d
C. Enhancement of selective presynaptic input onto neurons by overexpression of neuroligin variantse
Neuroligin 1 +B Neuroligin 1 −B Neuroligin 2 (always −B)
Enhancement of VGlut1: 4.7d, 1.5f 2.5d 5.3d, 1.5f
Enhancement of VGAT: 1.5d, 2.2f 5.0d 5.6d, 3.0f
a

Line widths reflect affinity of interaction. β-Neurexins that contain an insert at site 4 (+S4) interact preferentially with neuroligins that lack an insert at the B site (−B); they have lower affinity for +B neuroligin. β-Neurexins that lack an insert at site 4 (−S4) interact with −B neuroligins and +B neuroligin with equal affinity [9••,43••,44••].

b

Induction is reported normalized to 100% induction by neurexin 1β (−S4).

c

From [9••].

d

From [44••].

e

Enhancement is reported as increased density of inputs immunoreactive for VGlut (a marker of glutamatergic presynapses) or VGAT (a marker of GABAergic presynapses) relative to a value of 1.0 for control input density onto neurons expressing enhanced green fluorescent protein (EGFP). The neuroligin forms tested all contained the A-site insert.

f

From [35].

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